LORVIQUA® (lorlatinib) as monotherapy is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) previously not treated with an ALK inhibitor.1
LORVIQUA® (lorlatinib) as monotherapy is indicated for the treatment of adult patients with ALK-positive advanced NSCLC whose disease has progressed after:
A third generation ALK TKI, LORVIQUA® is designed to address the unmet medical needs of CNS progression and ALK resistance mutations2,3,4 and has demonstrated efficacy in both treatment-naïve patients and those whose disease had progressed on a previous ALK TKI.1,2,5
As a 2nd line therapy LORVIQUA® has a generally manageable safety profile, with a low permanent discontinuation rate (3.4%) due to treatment-related AEs* and a once-daily dosing schedule, taken with or without food.1,7
AE: Adverse Event, ALK: Anaplastic Lymphoma Kinase, CNS: Central Nervous System, NSCLC: Non-Small Cell Lung Cancer, TKI: Tyrosine-Kinase Inhibitor.
Footnotes:
*In the phase II portion of the Phase I/II registrational study (n=295), 3.4% of patients discontinued treatment due to a treatment-related adverse event.1,7
References
LORVIQUA®▼(lorlatinib) Prescribing Information for Great Britain and Northern Ireland click here.
XALKORI® (crizotinib) Prescribing Information for Great Britain and Northern Ireland click here.
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PP-UNP-GBR-7812. January 2024