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AboutAboutHow XELJANZ worksXELJANZ in ActionCytokinesSignalling PathwaysDosingDosingDosing in RADosing in UCDosing in PsADosing in pJIA and jPsADosing in ASSpecial Warnings & PrecautionsEfficacy & SafetyEfficacy & SafetySafety & TolerabilityOral SurveillanceAdverse EventsClinical Efficacy RAORAL Strategy Study DesignORAL Strategy Efficacy ResultsORAL Strategy Safety OutcomesClinical Efficacy UCOCTAVE Study DesignOCTAVE Sub GroupsOCTAVE InductionOCTAVE SustainPost-hoc AnalysesClinical Efficacy PsAOPAL Broaden & BeyondClinical Efficacy pJIA and jPsAJIA-1 Study DesignJIA-1 Efficacy ResultsJIA-1 Safety OutcomesClinical Efficacy ASASAS20/40 DataASDAS(CRP) DataReal World EvidenceReal World EvidenceReal World Evidence
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XELJANZ® (tofacitinib citrate) Prescribing Information and Maxtrex (methotrexate) Prescribing Information. Adverse event reporting can be found at the bottom of the page.
 
 Tofacitinib should only be used if no suitable treatment alternatives are available in patients:

  • 65 years of age and older;
  • patients with history of atherosclerotic cardiovascular disease or other cardiovascular risk factors (such as current or past long-time smokers);
  • patients with malignancy risk factors (e.g. current malignancy or history of malignancy)

 These risks are considered class effects and relevant across all approved indications of JAKi in inflammatory and dermatologic diseases.

Expert opinion:
Professor Patrick Kiely


Biography
Professor Kiely is a general rheumatologist and runs specialist clinics in difficult to manage rheumatoid arthritis, idiopathic inflammatory myositis, vasculitis and interstitial lung disease associated with rheumatic diseases. He also runs the only UK national clinic for people with haemochromatosis arthropathy.  

He was a member of the NICE guideline development group for rheumatoid arthritis in 2008–09, and Quality Standards group 2011–12. He has served on several British Society for Rheumatology committees and was Associate editor for Rheumatology 2017-2019. Currently he is convenor of the eular task force to develop classification criteria for haemochromatosis arthropathy, a member of the eular task force on biopharmaceutical monitoring in inflammatory arthritis and the BSR guideline development group for management of idiopathic inflammatory myositis.

His research interests are in the fields of outcomes and optimisation of therapies for inflammatory arthritis, especially biologic and JAK inhibitors, myositis and haemochromatosis arthropathy. He lectures widely in the UK and overseas on his areas of specialist interest and since 2008 has organised tri-annual educational meetings for consultant rheumatologists in London (South), Surrey, Sussex and Kent.

Spotlight on Xeljanz (tofacitinib citrate) in RA: a review of efficacy and safety from RWEThe role of Xeljanz (tofacitinib citrate) in rheumatology: A clinician perspectiveExplore moreRegister on PfizerPro today!Join us

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XELJANZ Risk Minimisation Programme (RMP) materials, including a Patient Alert Card, Prescriber Checklists and a Prescriber Brochure are available from https://www.medicines.org.uk/emc/. Patients treated with XELJANZ should be given the Patient Alert Card.
PP-XEL-GBR-4682. August 2023
Professor Patrick Kiely

Professor Patrick DW Kiely, PhD, FRCP, is a Consultant Rheumatologist at St George’s University Hospitals NHS Foundation Trust and Professor of Practice in Clinical Rheumatology at St George’s, University of London. He qualified in medicine from the Middlesex and University College Hospital Medical School (University of London) in 1988, attained a PhD degree from Cambridge University in 1996 and has been consultant at St George’s since 1999.

Rheumatoid Arthritis

Take a look at the Xeljanz ORAL Strategy studies by clicking below.

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Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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